01.05.2024 | editorial
Antibody–drug conjugates (ADC special)—part 1
Approximation to the magic bullet
Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 2/2024
Einloggen, um Zugang zu erhaltenExcerpt
The third generation of antibody–drug conjugates (ADCs) constitute a real breakthrough with a rapid expansion of this innovative treatment approach in different tumor types, making ADCs one of the fastest-growing classes of drugs in oncology. Because ADCs combine the targeting capacity of monoclonal antibodies and the high efficacy of chemotherapeutic payloads, they are not only very effective anticancer treatments, but also less toxic than systemically administered chemotherapeutics. Currently, a total of 15 different ADCs are US Food and Drug Administration (FDA)-approved for different indications, mainly in the metastatic setting. …Anzeige