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European Surgery
Erschienen in:

01.08.2013 | Original Article

APACHE II and Mannheim Peritonitis Index (MPI) fail to predict lethality in septic peritonitis in immunosuppressed solid organ transplant recipients

verfasst von: V. Assfalg, MD, D. Reim, MD, E. Matevossian, MD, B. Holzmann, MD, K. L. Emmanuel, MD, A. Novotny, MD, N. Hüser, MD

Erschienen in: European Surgery | Ausgabe 4/2013

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Summary

Background

We investigated the applicability of both Acute Physiology And Chronic Health Evaluation II (APACHE II) and Mannheim Peritonitis Index (MPI) in transplant recipients with intestinal perforation as polymicrobial peritonitis is highly life-threatening in patients with impaired immunological defence and the course of abdominal sepsis is aberrant compared to non-immunosuppressed individuals.

Methods

In a retrospective database analysis, we validated the consistency of APACHE II and MPI in death prediction in septic peritonitis. In a matched-pair analysis we then investigated their applicability in immunosuppressed transplant recipients. The validation of the scores was performed with 125 non-immunosuppressed patients. In a matched-pair analysis 16 immunosuppressed transplant recipients were compared with 32 controls.

Results

In accordance with clinical observations, statistical analyses revealed significantly higher MPI scores in immunosuppressed transplant recipients (P = 0.0007), whereas APACHE II scores were comparable. Linear regression analysis revealed that predicted death rates derived from APACHE II and MPI differ significantly (P = 0.0344) in immunosuppressed transplant recipients compared to controls.

Conclusions

Both scores consistently serve as reliable tools for prediction of lethality in septic peritonitis but they fail in immunosuppressed organ recipients. Our findings clearly confirm that in immunosuppressed patients severe peritonitis might be present despite an a- or oligosymptomatic clinical course.
Vorheriger Artikel Impact of tumor location on prognosis in patients with thoracic esophageal squamous cell carcinoma
Nächster Artikel Comparison of regenerated and non-regenerated oxidized cellulose hemostatic agents
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Metadaten
Titel
APACHE II and Mannheim Peritonitis Index (MPI) fail to predict lethality in septic peritonitis in immunosuppressed solid organ transplant recipients
verfasst von
V. Assfalg, MD
D. Reim, MD
E. Matevossian, MD
B. Holzmann, MD
K. L. Emmanuel, MD
A. Novotny, MD
N. Hüser, MD
Publikationsdatum
01.08.2013
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 4/2013
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-013-0218-8

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