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Wiener klinische Wochenschrift
Erschienen in:

01.12.2016 | geriatrics: at crossroads of medicine

Comparison of HE4 and CA125 levels in women with benign gynecologic disorders

Does age or menopausal status matter?

verfasst von: Ratko Delić, Mario Štefanović, Štefka Krivec, Vladimir Weber, Jakob Koren

Erschienen in: Wiener klinische Wochenschrift | Sonderheft 7/2016

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Summary Objective Methods Results Conclusion

The aim of this study was to measure serum concentrations of human epididymis protein 4 (HE4) in premenopausal and postmenopausal women with benign adnexal tumors and compare HE4 levels with those of cancer antigen 125 (CA125) measured in the same samples.
In a retrospectively designed, monocentric study (Department of Gynecology & Obstetrics, General Hospital, Celje, Slovenia, EU), 147 women diagnosed with various benign adnexal tumors were included. Preoperative HE4 and CA125 levels were obtained and analyzed with regard to histopathological classification, menopausal status, and age distribution.
A marked difference was observed in patients with endometriomas in which mean CA125 was elevated above the reference range in the premenopausal (mean 90.1 U/ml) and postmenopausal groups (mean 48.5 U/ml), while HE4 levels were within the reference range, irrespective of age or menopausal status. Inflammatory adnexal tumors were associated with elevated levels of CA125 (mean 142.2 U/ml, premenopausal and mean 62.4 U/ml, postmenopausal patients); HE4 levels were not elevated regardless of age or menopausal status.
HE4 is elevated less frequently than CA125 in benign adnexal tumors, regardless of age or menopausal status.
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Literatur
1.
Buys SS, Partridge E, Greene MH, et al. Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial. Am J Obstet Gynecol. 2005;193(5):1630–9.CrossRefPubMed
2.
Moore RG, Miller MC, Eklund EE, Lu KH, Bast RC Jr, Lambert-Messerlian G. Serum levels of the ovarian cancer biomarker HE4 are decreased in pregnancy and increase with age. Am J Obstet Gynecol. 2012;206(4):349.e1–349.e7. doi:10.​1016/​j.​ajog.​2011.​12.​028.CrossRef
3.
Park Y, Kim Y, Lee EY, Lee JH, Kim HS. Reference ranges for HE4 and CA125 in a large Asian population by automated assays and diagnostic performances for ovarian cancer. Int J Cancer. 2012;130(5):1136–44. doi:10.​1002/​ijc.​26129.CrossRefPubMed
4.
5.
6.
Delić R, Weber V. Parasitic myoma as an adnexal mass: unexpected finding after vaginal hysterectomy. Acta Clin Croat. 2016;55(2):290–2. doi:10.20471/acc.2016.55.02.16
7.
Bast RC Jr, Klug TL, John StE, et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med. 1983;309(15):883.CrossRefPubMed
8.
9.
10.
11.
12.
Karlsen MA, Høgdall EV, Christensen IJ, et al. A novel diagnostic index combining HE4, CA125 and age may improve triage of women with suspected ovarian cancer – An international multicenter study in women with an ovarian mass. Gynecol Oncol. 2015;138(3):640–6. doi:10.​1016/​j.​ygyno.​2015.​06.​021.CrossRefPubMed
13.
Holcomb K, Vucetic Z, Miller MC, Knapp RC. Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women. Am J Obstet Gynecol. 2011;205(4):358.e1–358.e6. doi:10.​1016/​j.​ajog.​2011.​05.​017.CrossRef
14.
15.
Cheng YM, Wang ST, Chou CY. Serum CA-125 in preoperative patients at high risk for endometriosis. Obstet Gynecol. 2002;99(3):375–80.PubMed
16.
17.
Pagana KD, Pagana TJ, Pagana TN. CA-125 tumor marker (Cancer antigen-125). In: Mosby’s diagnostic and laboratory test reference, 12th edn. St. Louis: Elselvier Mosby; 2015. pp. 199–200.
18.
Moley KH, Massad LS, Mutch DG. Pelvic inflammatory disease. Correlation of severity with CA-125 levels. J Reprod Med. 1996;41(5):341–6.PubMed
Metadaten
Titel
Comparison of HE4 and CA125 levels in women with benign gynecologic disorders
Does age or menopausal status matter?
verfasst von
Ratko Delić
Mario Štefanović
Štefka Krivec
Vladimir Weber
Jakob Koren
Publikationsdatum
01.12.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe Sonderheft 7/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-016-1099-1

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