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memo - Magazine of European Medical Oncology
Erschienen in:

21.02.2019 | educational

Educational no.5: next-generation gene panel sequencing

verfasst von: Wolfgang Kranewitter

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 2/2019

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Summary

Next-generation sequencing allows the simultaneous interrogation of a large number of genomic targets and is therefore highly suitable for situations, in which mutations in many different genes may have a clinical impact. This short educational discusses the process from the sample to the reported mutations and the limits of the method.
Vorheriger Artikel memo—publisher’s report 2018
Nächster Artikel Direct oral anticoagulants: a treatment option in oncological patients
Literatur
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Richards S, Aziz N, Bale S, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015;17(5):405–24.CrossRef
2.
Li MM, Datto M, Duncavage EJ, et al. Standards and guidelines for the interpretation and reporting of sequence variants in Cancer: a joint consensus recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists. J Mol Diagn. 2017;19(1):4–23.CrossRef
3.
Ståhlberg A, Krzyzanowski PM, Egyud M, Filges S, Stein L, Godfrey TE. Simple multiplexed PCR-based barcoding of DNA for ultrasensitive mutation detection by next-generation sequencing. Nat Protoc. 2017;12(4):664–82.CrossRef
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Le Gallo M, Lozy F, Bell DW. Next-generation sequencing. Adv Exp Med Biol. 2017;943:119–48.CrossRef
5.
Yohe S, Thyagarajan B. Review of clinical next-generation sequencing. Arch Pathol Lab Med. 2017;141(11):1544–57.CrossRef
Metadaten
Titel
Educational no.5: next-generation gene panel sequencing
verfasst von
Wolfgang Kranewitter
Publikationsdatum
21.02.2019
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 2/2019
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-019-0479-4

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