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memo - Magazine of European Medical Oncology
Erschienen in:

01.05.2014 | short review

Follow-up in aggressive lymphomas

verfasst von: Prof. Dr. Jan Walewski, MD

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 2/2014

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Abstract

A number of important contributions to the clinical knowledge of aggressive B-cell lymphoma were published over the past year. Among potential practice-changing studies—or those preventing unjustified change, were studies on improved risk classification, dose-dense immunochemotherapy, early autologous stem-cell transplantation, and the first clinical report on the use of immune checkpoint blockade to improve outcome of high-dose therapy.
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Literatur
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Zhou Z, Sehn LH, Rademaker AW, et al. An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era. Blood. 2014;123:837–42.
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Cunningham D, Hawkes EA, Jack A, et al. Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diff use large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensifi cation with 14-day versus 21-day cycles. Lancet. 2013;381:1817–26.
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Pfreundschuh M, Schubert J, Ziepert M, Clemens M, Peter N, Bokemeyer C, Eimermacher H, Anthony H German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL). Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20 + B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol. 2008;9:105–16.
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Pfreundschuh M, Trumper L, Osterborg A, et al. MabThera International Trial (MInT) Group. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomized controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol. 2006;7:379–91.
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Stiff PJ, Unger JM, Cook JR, et al. Autologous transplantation as consolidation for aggressive non-Hodgkin’s lymphoma. N Engl J Med. 2013;369:1681–90.
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Schmitz N, Nickelsen M, Ziepert M, et al. German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL). Conventional chemotherapy (CHOEP-14) with rituximab or high-dose chemotherapy (MegaCHOEP) with rituximab for young, high-risk patients with aggressive B-cell lymphoma: an open-label, randomised, phase 3 trial (DSHNHL 2002–1). Lancet Oncol. 2012;13:1250–59.
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Jacobsen ED. Restoring antitumor immunity via PD-1 blockade after autologous stem-cell transplantation for diffuse large B-cell lymphoma. J Clin Oncol. 2013;31:4268–70.
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Armand P, Nagler A, Weller EA, et al. Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial. J Clin Oncol. 2013;31:4199–206.
Metadaten
Titel
Follow-up in aggressive lymphomas
verfasst von
Prof. Dr. Jan Walewski, MD
Publikationsdatum
01.05.2014
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 2/2014
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-014-0141-0

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