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Wiener klinische Wochenschrift
Erschienen in:

01.01.2014 | letter to the editor

Gastrointestinal bleeding associated with dabigatran in a patient with panhypopituitarism

verfasst von: Fahri Gunes, MD, Mehmet Asik, MD, Ahmet Temiz, MD, Emine Binnetoglu, Hacer Sen, Ogun İrem Bilen, Erdem Akbal, MD, Gurhan Adam, Kubilay Ukinc

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 1-2/2014

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Excerpt

Dabigatran is a direct thrombin inhibitor that is used to reduce the risk of systemic embolism in patients with atrial fibrillation (AF). It does not require international normalised ratio (INR) monitoring during the course of treatment, and this arise from the most important advantage of this drug when compared with coumadin. The main complication of dagibatran is bleeding of the gastrointestinal system [1]. Bleeding diathesis, renal dysfunction, age, and concomitant antiplatelet medications are associated with bleeding complications [2]. …
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Literatur
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Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139–51.PubMedCrossRef
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Harper P, Young L, Merriman E. Bleeding risk with dabigatran in the frail elderly. The N Engl J Med. 2012;366(9):864–6.
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Oliveira MC, Kramer CK, Marroni CP, Leães CG, Viana L, Roithman S, et al. Acquired factor VIII and von Willebrand factor (aFVIII/VWF) deficiency and hypothyroidism in a case with hypopituitarism. Clin Appl Thromb Hemost. 2010;16:107–9.PubMedCrossRef
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Keleştimur F. Sheehan’s syndrome. Pituitary. 2003;6:181–8.
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Laway BA, Mir SA, Bashir MI, Bhat JR, Samoon J, Zargar AH. Prevalence of hematological abnormalities in patients with Sheehan’s syndrome: response to replacement of glucocorticoids and thyroxine. Pituitary. 2011;14:39–43.PubMedCrossRef
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Gokalp D, Tuzcu A, Bahceci M, Ayyildiz O, Erdemoglu M, Alpagat G. Assessment of bleeding disorders in Sheehan’s syndrome: are bleeding disorders the underlying cause of Sheehan’s syndrome? Platelets. 2011;22:92–7.PubMedCrossRef
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Karabulut Z, Dogˇan T, Asik M, Ergun T, Lakadamyalı H, Moray G. Spontaneous retroperıtoneal hematoma assocıated wıth enoxaparın: case report. Turkiye Klinikleri J Cardiovasc Sci. 2007;19:186–9.
Metadaten
Titel
Gastrointestinal bleeding associated with dabigatran in a patient with panhypopituitarism
verfasst von
Fahri Gunes, MD
Mehmet Asik, MD
Ahmet Temiz, MD
Emine Binnetoglu
Hacer Sen
Ogun İrem Bilen
Erdem Akbal, MD
Gurhan Adam
Kubilay Ukinc
Publikationsdatum
01.01.2014
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 1-2/2014
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-013-0454-8

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