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Wiener Medizinische Wochenschrift
Erschienen in:

01.01.2015 | main topic

IL-6 blockade in chronic inflammatory diseases

verfasst von: Antonia Puchner, MD, Stephan Blüml, MD

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 1-2/2015

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Summary

Proinflammatory cytokines are centrally involved in the pathogenesis of various rheumatic diseases. Interleukin (IL)-6 is a prototypic representative of this family. Basic research has uncovered a multitude of functions for this cytokine, such as immune regulation, hematopoiesis, inflammation, and oncogenesis (Fig. 1). In recent years, agents blocking the actions of IL-6 have been developed for the therapy of rheumatologic inflammatory diseases. While in some diseases, most notably rheumatoid arthritis, the clinical efficacy of these drugs was excellent, the results of clinical trials in other chronic inflammatory diseases were heterogeneous. In this review, we will summarize the data currently available on IL-6 blockade in chronic inflammatory diseases and will also discuss the safety issues of blocking this cytokine.
Vorheriger Artikel Anti-TNFs in axial spondyloarthritis
Nächster Artikel Blockade of co-stimulation in chronic inflammatory diseases
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Metadaten
Titel
IL-6 blockade in chronic inflammatory diseases
verfasst von
Antonia Puchner, MD
Stephan Blüml, MD
Publikationsdatum
01.01.2015
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 1-2/2015
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-014-0321-x

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