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memo - Magazine of European Medical Oncology
Erschienen in:

01.09.2014 | review

Importance of intraoperative radiation therapy in the treatment of soft tissue sarcoma: data at hand

verfasst von: Arpad Sztankay, MD

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 3/2014

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Abstract

Intraoperative radiation therapy (IORT) delivers a high single-dose radiation during surgery, which in combination with perioperative conventional fractionated external beam radiation therapy enables increase the total dose to the tumor bed without increasing normal tissue morbidity. Therefore, it can improve local tumor control. Numerous clinical studies have proved the feasibility and efficacy of IORT in patients with sarcomas of the trunk and extremities, as well as retroperitoneal tumors. In this publication, theoretical and practical essentials regarding the utilization of IORT in the multimodal treatment of sarcoma will be discussed.
Vorheriger Artikel Neoadjuvant chemotherapy for soft tissue sarcoma
Nächster Artikel Surgical aspects in the treatment of retroperitoneal soft tissue sarcomas
Literatur
1.
Rosenberg SA, et al. The treatment of soft tissue sarcomas of the extremities. Ann Surg. 1982;196:3005–15.CrossRef
2.
Yang JC, et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol. 1998;16:197–203.PubMed
3.
Pisters PWT, et al. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. 1996;14:859–68.PubMed
4.
LeVay J, et al. Outcome and prognostic factors in soft tissue sarcoma in the adult. Int J Radiat Oncol Biol Phys. 1993;27:1091–9.PubMedCrossRef
5.
Zagars KG, et al. Surgical margins and resection in the management of patients with soft tissue sarcoma using conservative surgery and radiation therapy. Cancer. 2003;97:2544–53.PubMedCrossRef
6.
Jebsen NL, et al. Radiotherapy to improve local control regardless of surgical margin and malignancy grade in extremity and trunk wall soft tissue sarcoma: a Scandinavian sarcoma group study. Int J Radiat Oncol Biol Phys. 2008;71:1196–203.PubMedCrossRef
7.
Gunderson LL, et al. Rationale and historical perspective of intraoperative irradiation. In: Gunderson LL, et al. editors. Intraoperative irradiation: techniques and results. Current clinical oncology. Totowa: Humana Press; 2011. p. 3–26.CrossRef
8.
Sindelar WF, et al. Intraoperative radiotherapy and retroperitoneal sarcomas. Final results of a prospective, randomized, clinical trial. Arch Surg. 1993;128:402–10.PubMedCrossRef
9.
Petersen IA, et al. Use of electron beam radiotherapy in the management of retroperitoneal soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 2002;52:469–75.PubMedCrossRef
10.
Petersen IA, et al. Use of intraoperative radiation therapy in retroperitoneal sarcomas: update of the Mayo Clinic Rochester Experience. ISIORT 2008 proceedings. Rev Cancer. 2008;22:57.
11.
Gieschen HL, et al. Long-term results of intraoperative electron beam radiotherapy for primary and recurrent retroperitoneal soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2001;50:127–31.PubMedCrossRef
12.
Krempien R, et al. Intraoperative radiation therapy (IORT) for primary and recurrent retroperitoneal soft tissue sarcoma: first results of a pooled analysis. ISIORT 2008 proceedings. Rev Cancer. 2008;22:56–7.
13.
Alektiar KM, et al. High-dose-rate intraoperative radiation therapy (HDR-IORT) for retroperitoneal sarcomas. Int J Radiat Oncol Biol Phys. 2000;47:157–63.PubMedCrossRef
14.
Dziewirski W, et al. Surgery combined with intraoperative brachytherapy in the treatment of retroperitoneal sarcomas. Ann Surg Oncol. 2006;13:245–52.PubMedCrossRef
15.
Petersen IA, et al. Extremity and trunk soft tissue sarcomas: EBRT with and without IORT. In: Gunderson LL, et al., editors. Intraoperative irradiation. Totowa: Humana Press; 1999. p. 359–78.CrossRef
16.
Callister MD, et al. Preoperative radiation and IORT for soft-tissue sarcomas of the extremities and trunk. Revisiones en Cancer. 2008;22:54.
17.
Azinovic I, et al. Intraoperative radiotherapy electron boost followed by moderate doses of external beam radiotherapy in resected soft – tissue sarcoma of the extremities. Radiother Oncol. 2003;67(3):331–7.PubMedCrossRef
18.
Oertel S, et al. Intraoperative electron boost followed by moderate doses of external beam radiotherapy in limb-sparing treatment of patients with extremity soft-tissue sarcoma. Int J Radiat Oncol Biol Phys. 2006;64:1416–23.PubMedCrossRef
19.
Niewald M, et al. Intraoperative radiotherapy (IORT) combined with external beam radiotherapy (EBRT) for soft tissue sarcomas – a retrospective evaluation of Homburg experience in the years 1995–2007. Radiat Oncol. 2009;4(1):32.PubMedCrossRefPubMedCentral
20.
Kretzler A, et al. Intraoperative radiotherapy of soft tissue sarcoma of the extremity. Strahlenther Onkol. 2004;180:365–70.PubMedCrossRef
21.
Rachbauer F, et al. High-dose-rate intraoperative brachytherapy (IOHDR) using flab technique in the treatment of soft tissue sarcomas. Strahlenther Onkol. 2003;179:480–5.PubMed
22.
Krempien R, et al. Intraoperative radiation therapy (IORT) for primary and recurrent extremity soft tissue sarcoma: first results of a pooled analysis. Revision en Cancer. 2008;22:56.
23.
Sztankay A, et al. Intraoperative HDR-AL Brachytherapie in Kombination mit perkutaner Radiotherapie bei marginal resezierten Weichteilsarkomen. Strahlenther Onkol. 2012;183(Suppl 1):189.
Metadaten
Titel
Importance of intraoperative radiation therapy in the treatment of soft tissue sarcoma: data at hand
verfasst von
Arpad Sztankay, MD
Publikationsdatum
01.09.2014
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 3/2014
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-014-0161-9

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