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Wiener Medizinische Wochenschrift
Erschienen in:

18.01.2022 | original article

Interleukin 10 rs1800896 and interleukin 1B rs16944 polymorphisms and the risk of cervical cancer

verfasst von: Jasenka Wagner, Sanela Štibi, Nikica Selak, Ilija Alvir, Ivica Mamić, Luka Marcelić, Lucija Šušnjar, Mario Puljiz, Marija Heffer, Damir Danolić

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 3-4/2023

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Summary

Background

The purpose of this study was to evaluate the relationships between interleukin 10 (IL10) (rs1800896) and interleukin 1B (IL1B) (rs16944) genetic polymorphisms and the risk for cervical cancer in a cohort of women from Croatia.

Methods

A case–control study of 81 patients with cervical cancer and 80 age-matched healthy controls was performed. We collected peripheral blood samples, extracted deoxiribonucleic acid (DNA), and analyzed two single-nucleotide polymorphisms (SNPs) rs1800896 and rs16944 using TaqMan assays (Fa. Thermo Fisher Scientific, Waltham, MA, USA) and real-time polymerase chain reaction (PCR). We investigated a possible association between two cytokine genetic polymorphisms and the occurrence of cervical cancer.

Results

Our results showed no significant difference in the frequency of IL10 (rs1800896) and IL1B (rs16944) genotypes between the patients and the controls (χ2 test, P < 0.05).

Conclusion

In this study, no association was found between IL10 rs1800896 and IL1B rs16944 polymorphisms and cervical cancer development.
Nächster Artikel Interleukin 10 rs1800896 and interleukin 1B rs16944 polymorphisms and cervical cancer: Correspondence
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Metadaten
Titel
Interleukin 10 rs1800896 and interleukin 1B rs16944 polymorphisms and the risk of cervical cancer
verfasst von
Jasenka Wagner
Sanela Štibi
Nikica Selak
Ilija Alvir
Ivica Mamić
Luka Marcelić
Lucija Šušnjar
Mario Puljiz
Marija Heffer
Damir Danolić
Publikationsdatum
18.01.2022
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 3-4/2023
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-021-00907-w

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