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Wiener klinische Wochenschrift OnlineFirst articles

Excessive smartphone use increases self-reported auditory and vestibular symptoms

  • Open Access
  • original article

Smartphones are undoubtedly one of the greatest inventions of recent times. These devices enable us to do much more than communicate; we can play games, listen to music, surf the internet, and perform many other activities [ 1 ]. Smartphones make …

PCSK9 inhibitors in real life—Cardiometabolic risk management in dyslipidemic patients in Vienna

  • Open Access
  • original article

Proprotein convertase subtilisin kexin type 9 inhibitors (PCSK9i) are an approved class of antilipemic agents that have emerged as therapeutic options for patients unable to achieve the low-density lipoprotein (LDL-C) target or to tolerate …

Addressing healthcare vulnerabilities in nursing homes

  • Open Access
  • original article

Individuals with severe psychiatric disorders, including affective and psychotic disorders as well as older citizens with dementia are frequently admitted to nursing homes due to a compromised physical and mental health [ 1 , 2 ]. In light of …

Healing chronic idiopathic eosinophilic pneumonia using mepolizumab alone without corticosteroids

  • Open Access
  • case report

While glucocorticoids remain the standard first-line treatment for chronic idiopathic eosinophilic pneumonia (CIEP), the long-term use is marred by significant side effects. This case study explores the effectiveness of mepolizumab, an …

Does surgeon or hospital volume influence outcome in dedicated colorectal units?—A Viennese perspective

  • Open Access
  • original article

Colorectal cancer (CRC) remains the third most commonly diagnosed cancer worldwide, accounting for approximately 1.9 million new cases annually [ 1 ]. Despite the implementation of screening programs, a better understanding of the underlying …

Genetic relationship between rheumatoid arthritis and cardiovascular diseases

  • Open Access
  • review article

RA is a chronic autoimmune disease characterized by systemic inflammation and synovial joint destruction. It affects approximately 1% of the global population, with a higher prevalence among women [ 1 ]. While RA primarily targets the joints …

Analysis of the impact of a university distance learning course on digitalization in medicine on students and healthcare professionals

  • Open Access
  • original article

Digitalization entered the healthcare sector years ago, and the number of digital applications is growing rapidly. This increasing number of future digital health applications can easily be seen in the application process of the US Food and Drug …

A causal relationship between hypothyroidism and rheumatoid arthritis, but not hyperthyroidism: evidence from the mendelian randomization study

  • Open Access
  • original article

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by symmetrical multiarticular synovitis. Inflammatory cell infiltration results in the degeneration of synovitis, articular cartilage, and bone [ 1 , 2 ]. RA primarily …

Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion

  • Open Access
  • original article

Stroke resulting from large vessel occlusion (LVO) of the proximal middle cerebral artery (MCA) is a devastating disease and a significant contributor to loss of independence [ 1 ]. Endovascular thrombectomy (EVT) as a reperfusion procedure for …

25 years of lipid-lowering therapy: secular trends in therapy of coronary patients

  • original article

The most prominent and causal risk factor for cardiovascular events and progression of cardiovascular disease is low-density lipoprotein cholesterol (LDL-C) [ 1 ]. Hence, historical guidelines have consistently advised the regulation of LDL‑C [ 2 …3

Gene therapy: principles, challenges and use in clinical practice

  • Open Access
  • review article

Already in 1972, Friedmann and Roblin hypothesized that genetic modification might be the way to cure hereditary diseases [ 1 ]. Following many years of scientific groundwork and technical advancements, the first clinical gene therapy studies …

The Landsteiner lung cancer research platform (LALUCA)

  • Open Access
  • original article

Lung cancer is the most common cause of cancer-related deaths and the second most frequently diagnosed cancer worldwide [ 1 ]. As in the rest of the world, lung cancer is a major health burden in Austria comprising 19% of all cancer deaths. With …

Perspectives in treatment-resistant depression: esketamine and electroconvulsive therapy

  • perspective

Modern electroconvulsive therapy (ECT) and the approval of nasal esketamine for clinical use have significantly improved the approach to treatment-resistant depression (TRD), which is defined as non-response to at least two different courses of …