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Wiener klinische Wochenschrift
Erschienen in:

01.10.2015 | case report

Life-threatening acute pneumonitis in mixed connective tissue disease: a case report and literature review

verfasst von: Eva Rath, Shahin Zandieh, Alexander Löckinger, Mirko Hirschl, Klaus Klaushofer, Jochen Zwerina

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 19-20/2015

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Summary

Mixed connective tissue disease (MCTD) is a rare connective tissue disease frequently involving the lungs. The main characteristic is a systemic sclerosis-like picture of slowly progressing interstitial lung disease consistent with lung fibrosis, while pulmonary arterial hypertension is rare. Herein, we present a case of a newly diagnosed MCTD patient developing life-threatening acute pneumonitis similar to lupus pneumonitis. Previous literature on this exceptionally rare complication of MCTD is reviewed and differential diagnosis and management discussed.
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Literatur
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Tani C, Carli L, Vagnani S, et al. The diagnosis and classification of mixed connective tissue disease. J Autoimmun. 2014;48–49:46–9.CrossRefPubMed
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Gunnarsson R, Aaløkken TM, Molberg Ø. Prevalence and severity of interstitial lung disease in mixed connective tissue disease: a nationwide, cross-sectional study. Ann Rheum Dis. 2012;71(12):1966–72.CrossRefPubMed
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Gunnarsson R, Andreassen AK, Molberg Ø. Prevalence of pulmonary hypertension in an unselected, mixed connective tissue disease cohort: results of a nationwide, Norwegian cross-sectional multicentre study and review of current literature. Rheumatology (Oxford). 2013;52(7):1208–13.CrossRef
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Pego-Reigosa JM, Medeiros DA, Isenberg DA. Respiratory manifestations of systemic lupus erythematosus: old and new concepts. Best Pract Res Clin Rheumatol. 2009;23(4):469–80.CrossRefPubMed
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Takeda T, Tsutsumi A, Ogura N, et al. A case of mixed connective tissue disease with acute interstitial pneumonitis. Nihon Rinsho Meneki Gakkai Kaishi. 1995;18(3):303–7.CrossRefPubMed
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Fernandes C, Bungay P, O’Driscoll BR, Herrick AL. Mixed connective tissue disease presenting with pneumonitis and pneumatosis intestinalis. Arthritis Rheum. 2000;43(3):704–7.CrossRefPubMed
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Watanabe Y, Koyama S, Moriguchi M, et al. Rapidly progressive respiratory failure in mixed connective tissue disease: report of an autopsy case. Intern Med. 2012;51(24):3415–9.CrossRefPubMed
Metadaten
Titel
Life-threatening acute pneumonitis in mixed connective tissue disease: a case report and literature review
verfasst von
Eva Rath
Shahin Zandieh
Alexander Löckinger
Mirko Hirschl
Klaus Klaushofer
Jochen Zwerina
Publikationsdatum
01.10.2015
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 19-20/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-015-0823-6

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