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Wiener klinische Wochenschrift
Erschienen in:

31.07.2017 | original article

Moderate alcohol consumption and atherosclerosis

Meta-analysis of effects on lipids and inflammation

verfasst von: Yunying Huang, Yongmei Li, Sichao Zheng, Xin Yang, Tenghua Wang, Jie Zeng

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 21-22/2017

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Summary

Objective

Alcohol consumption plays an important role in the risk of major cardiovascular diseases. We conducted a meta-analysis to summarize the association between moderate alcohol consumption and atherosclerosis.

Design

In this study four databases and reference lists of retrieved articles were searched to identify eligible studies. A meta-analysis was carried out of all interventional studies that assessed the effects of moderate alcohol consumption on concentrations of low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, apolipoprotein A I, interleukin 6, plasminogen activator inhibitor 1, fibrinogen, and other biomarkers previously found to be associated with risk of atherosclerosis.

Results

A total of 31 studies met the eligibility criteria. In response to moderate alcohol consumption, low density lipoprotein cholesterol decreased by 0.08 mmol/l (P = 0.05), and high density lipoprotein cholesterol increased by 0.08 mmol/l (P < 0.00001), whereas total cholesterol and triglyceride remained the same. Moreover, interleukin 6 decreased by 0.43 pg/ml (P = 0.03), whereas C‑reactive protein and tumor necrosis factor a remained the same. Several hemostatic factors and adiponectin were modestly affected by alcohol consumption.

Conclusion

Moderate alcohol consumption is causally related to lower risk of atherosclerosis through changes in lipid profiles and inflammation.
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Metadaten
Titel
Moderate alcohol consumption and atherosclerosis
Meta-analysis of effects on lipids and inflammation
verfasst von
Yunying Huang
Yongmei Li
Sichao Zheng
Xin Yang
Tenghua Wang
Jie Zeng
Publikationsdatum
31.07.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 21-22/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-017-1235-6

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