Skip to main content
Home
Zeitschriften
Zeitungen
Podcast
Gesundheitspolitik
Praxis
Allerlei
Jobs
Fachgebiete
Allgemeinmedizin Anästhesiologie & Intensivmedizin Apotheke Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kinder & Jugendheilkunde Neurologie & Psychiatrie Orthopädie & Unfallchirurgie Pflege Urologie Zahnmedizin
Subfächer Innere Medizin
Diabetologie Gastroenterologie Infektiologie Kardiologie Onkologie und Hämatologie Pneumologie Rheumatologie
Fortbildungen
Überblick Fortbildungen DFP-Literaturstudium-Artikel DFP-Webcast Fortbildungen DFP-Podcasts
Erweiterte Suche
Anmelden
nach oben
Wiener Medizinische Wochenschrift
Erschienen in:

01.03.2014 | main topic

Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group

verfasst von: Christopher J. Centeno, MD, Michael D. Freeman, PhDMPH

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 5-6/2014

Einloggen, um Zugang zu erhalten

Summary

In the present study, we describe six patients who received autologous mesenchymal stem cell (MSC) therapy for symptomatic carpometacarpal (CMC) joint and hand osteoarthritis (OA). Six patients who received injections of adult autologous culture expanded MSCs in their thumb CMC joints were followed for 1 year posttreatment, and matched with four procedure candidates who remained untreated. We observed positive outcomes in the treatment group for both symptoms and function related to the OA, compared with a reported worsening among the untreated controls. While these results should be interpreted with caution because of the small number of treated subjects and lack of placebo control and randomization, we find sufficient evidence for further investigation of MSC therapy as an alternative to more invasive surgery in patients with OA of the hand.
Vorheriger Artikel Bioregenerative medicine
Nächster Artikel Boundary cartilage lubrication: review of current concepts
Literatur
1.
Alhadlaq A, Mao JJ. Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev. 2004;13(4):436–48.PubMedCrossRef
2.
Arnoczky SP. Building a meniscus. Biologic considerations. Clin Orthop Relat Res. 1999;(367 Suppl):244–53.
3.
Wakitani S, et al. Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. J Tissue Eng Regen Med. 2007;1(1):74–9.PubMedCrossRef
4.
Wakitani S, et al. Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. J Tissue Eng Regen Med. 2010;5(2):146–50.
5.
Nejadnik H, et al. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am J Sports Med. 2010;38(6):1110–6.
6.
Centeno CJ, et al. Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells. Med Hypotheses. 2008;71(6):900–8.PubMedCrossRef
7.
Centeno CJ, et al. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008;11(3):343–53.PubMed
8.
Centeno CJ, et al. Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer: a case study. Pain Physician. 2006;9(3):253–6.PubMed
9.
Centeno CJ, et al. Safety and complications reporting on the reimplantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem Cell Res Ther. 2010;5(1):81–93.PubMedCrossRef
10.
Kalichman L, Hernandez-Molina G. Hand osteoarthritis: an epidemiological perspective. Semin Arthritis Rheum. 2010;39(6):465–76.PubMedCrossRef
11.
Schoffl VR, et al. Radiographic adaptations to the stress of high-level rock climbing in junior athletes: a 5-year longitudinal study of the German Junior National Team and a group of recreational climbers. Am J Sports Med. 2007;35(1):86–92.PubMedCrossRef
12.
Lee KB, et al. Acute calcific periarthritis of proximal interphalangeal joint in a professional golfer’s hand. J Korean Med Sci. 2004;19(6):904–6.PubMedCentralPubMedCrossRef
13.
Buterbaugh GA, Brown TR, Horn PC. Ulnar-sided wrist pain in athletes. Clin Sports Med. 1998;17(3):567–83.PubMedCrossRef
14.
15.
Earp BE, et al. Arthroscopic hemitrapeziectomy with tendon interposition for arthritis at the first carpometacarpal joint. Tech Hand Up Extrem Surg. 2008;12(1):38–42.PubMedCrossRef
16.
Wollstein R, et al. Long-term durability of tendon arthroplasty with excision of the trapezium in stage 1 osteoarthritis of the thumb CMC joint. Ann Plast Surg. 2009;62(4):358–60.PubMedCrossRef
17.
Hofmeister EP, et al. Arthroscopic hemitrapeziectomy for first carpometacarpal arthritis: results at 7-year follow-up. Hand (NY). 2009;4(1):24–8.CrossRef
18.
Hansen TB, Vainorius D. High loosening rate of the Moje Acamo prosthesis for treating osteoarthritis of the trapeziometacarpal joint. J Hand Surg Eur Vol. 2008;33(5):571–4.PubMedCrossRef
19.
Nilsson A, et al. The Artelon CMC spacer compared with tendon interposition arthroplasty. Acta Orthop. 2010;81(2):239–46.CrossRef
20.
Badia A, Sambandam SN. Total joint arthroplasty in the treatment of advanced stages of thumb carpometacarpal joint osteoarthritis. J Hand Surg Am. 2006;31(10):1605–14.PubMedCrossRef
21.
Bernardo ME, et al. Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute. J Cell Physiol. 2007;211(1):121–30.PubMedCrossRef
22.
Capelli C, et al. Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts. Bone Marrow Transplant. 2007;40(8):785–91.PubMedCrossRef
23.
Doucet C, et al. Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications. J Cell Physiol. 2005;205(2):228–36.PubMedCrossRef
24.
Lange C, et al. Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine. J Cell Physiol. 2007;213(1):18–26.PubMedCrossRef
25.
Muller I, et al. Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM. Cytotherapy. 2006;8(5):437–44.PubMedCrossRef
26.
Schallmoser K, et al. Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion. 2007;47(8):1436–46.PubMedCrossRef
27.
Sodha S, et al. Prevalence of osteoarthrosis of the trapeziometacarpal joint. J Bone Joint Surg Am. 2005;87(12):2614–8.PubMedCrossRef
28.
Katsube Y, et al. Correlation between proliferative activity and cellular thickness of human mesenchymal stem cells. Biochem Biophys Res Commun. 2008;368(2):256–60.PubMedCrossRef
29.
Agashi K, Chau DY, Shakesheff KM. The effect of delivery via narrow-bore needles on mesenchymal cells. Regen Med. 2009;4(1):49–64.PubMedCrossRef
30.
Sharma L. Comment on: varus malalignment negates the structure-modifying benefits of doxycycline in obese women with knee osteoarthritis. Osteoarthr Cartil. 2010;18(8):1006–7.PubMedCentralPubMedCrossRef
31.
Nuesch E, et al. Doxycycline for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2009;4:CD007323.
32.
Hunter DJ, Hellio Le Graverand-Gastineau MP. How close are we to having structure-modifying drugs available? Rheum Dis Clin North Am. 2008;34(3):789–802.PubMedCrossRef
33.
Le Graverand MP, et al. Assessment of the radioanatomic positioning of the osteoarthritic knee in serial radiographs: comparison of three acquisition techniques. Osteoarthr Cartil. 2006;14(Suppl A):A37–43.PubMedCrossRef
34.
Brandt KD, Mazzuca SA. Experience with a placebo-controlled randomized clinical trial of a disease-modifying drug for osteoarthritis: the doxycycline trial. Rheum Dis Clin North Am. 2006;32(1):217–34, xi–xii.PubMedCrossRef
35.
Filardo G, et al. Platelet-rich plasma intraarticular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2010;19(4)528–35.
36.
Gobbi A, Bathan L. Biological approaches for cartilage repair. J Knee Surg. 2009;22(1):36–44.PubMedCrossRef
37.
Sanchez M, et al. Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study. Clin Exp Rheumatol. 2008;26(5):910–3.PubMed
Metadaten
Titel
Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group
verfasst von
Christopher J. Centeno, MD
Michael D. Freeman, PhDMPH
Publikationsdatum
01.03.2014
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 5-6/2014
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-013-0222-4

Weitere Artikel der Ausgabe 5-6/2014

Boundary cartilage lubrication: review of current concepts

  • review

Darbepoetin alfa once every 2 weeks effectively maintained hemoglobin in dialysis patients in an observational study: Austrian cohort of ALTERNATE

  • original article

Medicinal leech therapy in pain syndromes: a narrative review

  • main topic

Medizinische Aspekte gängiger nicht-letaler Wirkmittel

  • originalarbeit

Bioregenerative medicine

  • editorial