01.07.2012 | Kalzium in der kardialen Pathophysiologie
Pharmacology of myocardial calcium-handling
Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 13-14/2012
Einloggen, um Zugang zu erhaltenSummary
Disturbed myocardial calcium (Ca+) handling is one of the pathophysiologic hallmarks of cardiovascular diseases such as congestive heart failure, cardiac hypertrophy, and certain types of tachyarrhythmias. Pharmacologic treatment of these diseases thus focuses on restoring myocardial Ca2+ homeostasis by interacting with Ca2+-dependent signaling pathways. In this article, we review the currently used pharmacologic agents that are able to restore or maintain myocardial Ca2+ homeostasis and their mechanism of action as well as emerging new substances.
Anzeige