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Wiener Medizinische Wochenschrift
Erschienen in:

27.01.2021 | original article

The snowdrop, wellspring of galanthamine

A brief descriptive and scientific history

verfasst von: Dimitri A. Cozanitis, BPharm, DMSc, DTMH

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 9-10/2021

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Summary

A history of the common snowdrop, Galanthus nivalis, is set out in folkloric fashion. Its religious connection is evident as well as the inspiration it arouses in artists and in ordinary persons. It is intended to shed light on the initial works relating to the snowdrop’s alkaloid, galanthamine, performed by Soviet and Bulgarian scientists, which lie buried away and generally remain unknown. A brief history and nature of alkaloids continues with the emphasis placed on galanthamine. Heretofore hidden uses of snowdrops in traditional (folk) medicine are unveiled. An anticholinesterase with central and peripheral activity, feasible clinical indications with galanthamine are described. Certain disorders for which galanthamine has been deemed beneficial are presented for their historical value. Ongoing research regarding drugs and chemicals developed from the snowdrop and galanthamine is mentioned.
Vorheriger Artikel Der nutz auß den Krautgärten. Georg Henischs Übersetzungen pharmazeutischer Werke
Nächster Artikel Von der anatomischen Lehrsektion zum Unterricht am Krankenbett – eine geschichtliche Würdigung
Fußnoten
1
Professor Valentyna Minarchenko, M.G. Kholodny Institute of Botany, Kiev, December 9, 2016, personal communication.
 
Literatur
1.
2.
Moldenke HN, Moldenke AL. Plants of the Bible. New York: Dover; 1952.
3.
Galanthus plicatus. Gardeners’ Chronicle & Agricultural Gazette, 17 May 1856.
4.
Two snowdrops. The New Flora and Silva 1939;11:226.
5.
Allen J. Snowdrops. J Royal Hortic Soc. 1891;13:172–88.
6.
Bernhard-Smith A. Poisonous plants of all countries. London: Baillière, Tindall & Cox; 1923.CrossRef
7.
Quinn V. Stories and legends of garden flowers. New York: Stokes; 1939.
8.
Ivanov VE. Poisonous plants. House: Primotrsky Provincial Reference Bureau Publishing; 1923. in Russian.
9.
Forsyth AA. British poisonous plants. London: HRM Stationery Office; 1954.
10.
School children in poison scare. East Anglian Daily Times, 2 May 2009.
11.
Grossheim AA. Plant wealth in the Caucasus. Moscow Society of Naturalists, New Series, Vol. 7 (XV). 1952. in Russian.
12.
Rendall V. Wild flowers in literature. London: Scholartis Press; 1934.
13.
Vogel M. Sur la découverte de l’acid méconique et de la morphine. J Pharm Sci Accessoires. 1920;6:179.
14.
Komarov V, editor. Lilliflorae and microspermae. Flora of the USSR, Vol. 4. Leningrad: The Botanical Institute of the Academy of Sciences of the USSR; 1935. transl.
15.
Perce-Neige. Dictionaire des Sciences Médicales, Vol. 40. Paris: Panckoucke; 1819. pp. 210–1.
16.
17.
Proskurnina NF, Areshkina PA. On the alkaloids of Galanthus woronowi. Z Obshch Khim. 1947;17:1216–9. in Russian.
18.
Proskurnina NF, Yakovleva AP. On the alkaloids of Galanthus wonorowi II. Isolation of a new alkaloid. Zh Obshch Khim. 1952;22:1899–902. in Russian.
19.
Proskurnina NF, Yakovleva AP. On the alkaloids of Galanthus wonorowi III. On the structure of galanthamine. Zh Obshch Khim. 1957;25:1035–9. in Russian.
20.
Wildman WC. Alkaloids of Amaryllidaeceae. In: Manske RHF, editor. The Alkaloids. Vol. 6. New York: Academic Press; 1960. p. 376.
21.
Harris LS, Dewey WL, Howes JF, et al. Narcotic-antagonist analgesics: interactions with cholinergic systems. J Pharmacol Exp Therap. 1969;169:17–22.
22.
Pedigo NW, Dewey WL. Acetylcholine-induced antinociception: comparisons to opiate analgesia. In: Pepeu G, Ladinsky H, editors. Cholinergic mechanisms. New York: Plenum; 1981p. pp. 795–804.CrossRef
23.
Cozanitis DA, Friedmann T, Furst S. Study of the analgesic effects of galanthamine, a cholinesterase inhibitor. Arch Int Pharmacodyn Ther. 1983;266:229–38.PubMed
24.
Mashkovsky MD, Kruglikova-Lvova RP. On the pharmacology of the new alkaloid galanthamine. Farmakol Toksikol. 1951;14(6):26–30. in Russian.
25.
Riker WF Jr, Wescoe WC. The direct action of prostigmine on skeletal muscle; its relationship to the choline esters. J Pharmacol Exp Ther. 1946;88:58–66.PubMed
26.
Ivanova-Bubeva L. Phytochemical examination of Galanthus nivalis var. gracilis. Farmacia. 1957;2:23–6. in Bulgarian.
27.
Cozonitis [sic] DA. Lest we forget. Am J Hosp Pharm. 1991;48:463. Letter.
28.
Cherkasov CA. Plant sources of galanthamine. Khim Farm Zh. 1977;11:84–7. transl.
29.
Kikodze D. Assessing harvest levels for Galanthus woronowii Losinsk. in Georgia and the challenge of producing a non-detriment finding. NDF workshop case studies. WG 4‑geophytes and epiphytes, case study 2. 2008. pp. 1–11.
30.
Do daffodils hold key to Alzheimer’s? Sunday Express, 19 March 1995.
31.
Alzheimer cure hope is growing. Daily Express (Scot), 10 June 1995.
32.
Shenk NA, Eidinova MB, Mitbreit IM. Therapeutic and diagnostic value of galanthamine in the cases of patients with different stages of poliomyelitis. Farmakol Toksikol. 1956;19:36–41. in Russian.PubMed
33.
Paskov DA. Una nuova sostanza nella terapia delle paralisi poliomielitiche la nivalina. Cult Med (Roma). 1960;16:1–6.
34.
Revelli U, Grasso E. Le traitment de la poliomyelite a la nivalin. Minerva Med. 1962;53:881–2.PubMed
35.
The little white flower. The Evening News (London). 3 March 1960. p.13.
36.
Ikonomoff SI. Cerebrocardiac form of migraine: clinical picture and treatment. Headache. 1967;7:18–22.PubMedCrossRef
37.
Deredjan A, Krasteva E. Our observations on decurarization effect of nivalin. Khirurgia (Sofia). 1960;13:272–5. in Bulgarian.
38.
Mayrhofer O. Clinical experience with diallylnortoxiferine and curare antidote galanthamine. South Med J. 1966;52:1364–8.CrossRef
39.
Wislicki L. Nivaline (Galanthamine hydrobromide) an additional decurarizing agent. Some introductory observations. Br J Anaesth. 1967;39:963–8.PubMedCrossRef
40.
Salvini L, Frosali L, Pacet AM. Valutazione clinica dell’ antagonism verso la d‑tubocurarina di un nuovo anticholinesterasico (Nivalina). Minerva Anestesiol. 1962;28:201–4.PubMed
41.
Cozanitis DA, Nuuttila K, Karhunen P, et al. Changes in cardiac rhythm with galanthamine hydrobromide. Anaesthesist. 1973;22:457–9.PubMed
42.
Cozanitis DA. Galanthamine hydrobromide, a longer acting anticholinesterase drug in the treatment of the central effects of scopolamine (hyoscine). Anaesthesist. 1977;26:649–50.PubMed
43.
Lightwood R, Brimblecombe FSW, editors. Donald Paterson’s sick children. 8th ed. London: Cassell; 1963p. p. 444.
44.
Paskov D, Spallone M. La nivaline (galanthamine). Sa pharmacodynamie et son application thérapeutique. Cult Med (Roma). 1960;17:251–9.
45.
Perlstein MA, Barnett HE. Neostigmine therapy in cerebral palsy. JAMA. 1950;142:403–7.CrossRef
46.
Pernov K, Samardjiev A, Nikolkov V. Il trattamento delle distrofie musculari con dose elevate di nivalina. Cult Med. 1961;21:4–16.
47.
Abidov AA, Abdukhakimov A, Mukhamedov SM, et al. Antimicrobical properties of alkaloids isolated from plants of Central Asia. Uzbeksk Biol Zh. 1962;6:84–9. in Russian.
48.
Abidov AA, Abdusamatov MA, Kalinina EF, et al. Activity of some alkaloids extracted from middle Asian plant toward bacteria of the intestinal and coccus groups. Antimicrobial effect of Ungernia alkaloids. Uzbeksk Biol Zh. 1967;11:13–5. in Russian.
49.
Fitzgerald DB, Hartwell JL, Leiter J. Tumor-damaging activity in plant families showing antimalarial activity. Amaryllidaceae. J Natl Cancer Inst. 1958;20:763–74.PubMed
50.
Aeschlimann JA, Reinert M. The pharmacological action of some analogues of physostigmine. J Pharmacol Exp Ther. 1931;43:413–44.
51.
Sedloev S, Georgiev IV, Milev M. On the effect of nivalin upon interstinal peristalsis. Acta Inst Sup Med (Sofia). 1964;43:69–73.
52.
Walker MB. Treatment of myasthenia gravis with physostigmine. Lancet. 1934;223:1200–1.CrossRef
53.
Pestel M. Une nouvelle medication de la myasthenie et des dystrophies neuro-musculaires. Presse Med. 1961;69:182–3.PubMed
54.
Umarova S, Zakirov UB, Kamilov IK. Effect of galanthamine hydrobromide and hydromethylate on intraocular pressure. Dokl Akad Nauk Uzb. 1969;26:31–4. in Russian.
55.
Kilimov N. Trattamento della nevralgie del nervo trigemino. Cult Med (Roma). 1961;23:331–41.
56.
Göpel W, Bertram W. Erfahrungen mit Nivalin in der neurologischen Therapie. Psychiat Neurol Med Psychol (Leipzig). 1971;23:712–8.
57.
Cozanitis DA, Toivakka E, Dessypris A. Electroencephalographic and blood chemistry responses to galanthamine hydrobromide in epileptic volunteers. Anaesthesist. 1973;22:31–3.PubMed
58.
Isakova TP. Influence of nivaline and amisyl on human electroencephalograms and orienting responses. Zh Vyssh Nerv Deiat. 1965;15:1113–22. in Russian.PubMed
59.
Kraus VA. Interrelations between ventral and dorsal hippocampus in improvement and deterioration of short term memory. Zh Vissh Nervn Deyateln. 1974;24:33–41. in Russian.
60.
Dal-Bianco P, May J, Wöber C, et al. Galanthamine treatment in Alzheimer’s Disease. J Neurol Transm. 1991;33(Suppl):59–63.
61.
Sweeney JE, Höhmann CF, Moran TH, et al. A long-acting cholinesterase inhibitor reverses special memory deficits in mice. Pharmacol Biochem Behav. 1988;31:141–7.PubMedCrossRef
62.
Takos AM, Rook F. Towards a molecular understanding of the biosynthesis of Amaryllidaceae alkaloids in support of their expanding medical use. Int J Mol Sci. 2013;14:11713–41.PubMedPubMedCentralCrossRef
63.
Arndt W. To the slanderers of Russia. In: Alexander Pushkin—Collected narrative and lyrical poetry. Ann Arbor: Ardis; 1989, p. 104. Transl.
64.
Tsvetkova DD, Obreshkova DP, Petkova VB. Investigation of proliferative activity of Galantamine peptide derivate GAL-VAL against 3T cell lines. World J Pharm Pharm Sci. 2014;3:10–9.
65.
Mann K, Ackermann K, Diehl A, et al. Galantamine: a cholinergic patch in the treatment of alcoholism: a randomized, patch-controlled trial. Psychopharmacology. 2006;184:115–21.PubMedCrossRef
66.
Stoger E, Williams S, Christoul P, et al. Expression of the insecticidal lectin from snowdrop (Galanthus nivalis agglutinin; GNA) in transgenic wheat plants: effects on predation by the grain aphid Sitobion avenae. Fauna Flora Int. 2014;48:345–53.
Metadaten
Titel
The snowdrop, wellspring of galanthamine
A brief descriptive and scientific history
verfasst von
Dimitri A. Cozanitis, BPharm, DMSc, DTMH
Publikationsdatum
27.01.2021
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 9-10/2021
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-020-00799-2

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