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Wiener klinische Wochenschrift
Erschienen in:

01.01.2014 | case report

Bilateral pulmonary embolism in twins with PAI-1 4G/5G gene polymorphism: a case report

verfasst von: Andreas Kronbichler, MD, Prof. Peter Oelzner, Priv. Doz. Günter Syrbe, Eric Lopatta, MD, Prof. Gunter Wolf, Thomas Neumann, MD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 1-2/2014

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Summary

The aetiology of venous thromboembolism in adolescents is frequently associated with hereditary abnormalities of the coagulation system, autoimmune disorders or malignancies. The advent of specific laboratory tests has refined the identification of genetic traits. In this case report, we describe the occurrence of pulmonary embolism in young twins. Intensive tumour screening remained unremarkable. Evaluation of established risk factors for a clotting disorder remained negative, with the exception of a plasminogen activator inhibitor-1 4G/5G polymorphism. Despite the mild association accompanied by the presence of the 4G allele, this polymorphism might predispose to venous thromboembolism in some cases in general and in our case in particular.
Vorheriger Artikel Epidemiology of traumatic brain injury in Austria
Nächster Artikel Therapeutic peritoneal lavage with warm saline solution as an option for a critical hypothermic trauma patient
Literatur
1.
Tsantes AE, Nikolopoulos GK, Bagos PG, Bonovas S, Kopterides P, Vaiopoulos G. The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk. Thromb Res. 2008;122(6):736–42.PubMedCrossRef
2.
Francis CW. Plasminogen activator inhibitor-1 levels and polymorphisms. Arch Pathol Lab Med. 2002 Nov;126(11):1401–4.PubMed
3.
Gramling MW, Church FC. Plasminogen activator inhibitor-1 is an aggregate response factor with pleiotropic effects on cell signaling in vascular disease and the tumor microenvironment. Thromb Res. 2010 May;125(5):377–81.PubMedCentralPubMedCrossRef
4.
Hoekstra T, Geleijnse JM, Schouten EG, Kok FJ, Kluft C. Relationship of C-reactive protein with components of the metabolic syndrome in normal-weight and overweight elderly. Nutr Metab Cardiovasc Dis. 2005 Aug;15(4):270–8.PubMedCrossRef
5.
Tsantes AE, Nikolopoulos GK, Bagos PG, Rapti E, Mantzios G, Kapsimali V, et al. Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosis. A meta-analysis. Thrombosis and haemostasis. 2007 Jun;97(6):907–13.
Metadaten
Titel
Bilateral pulmonary embolism in twins with PAI-1 4G/5G gene polymorphism: a case report
verfasst von
Andreas Kronbichler, MD
Prof. Peter Oelzner
Priv. Doz. Günter Syrbe
Eric Lopatta, MD
Prof. Gunter Wolf
Thomas Neumann, MD
Publikationsdatum
01.01.2014
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 1-2/2014
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-013-0443-y

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