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memo - Magazine of European Medical Oncology
Erschienen in:

01.06.2012 | short review

Breast cancer: is there a need for biopsy of metastases?

verfasst von: Flora Zagouri, MD, PhD, Martin Filipits, PhD

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 2/2012

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Abstract

Hormone receptors and the human epidermal growth factor receptor 2 (HER2) are important pharmaceutical targets that affect the survival of patients with metastatic breast cancer. Knowledge of their expression and/or amplification status is crucial for determining the optimal treatment. However, a discordance of hormone and HER2 receptors of primary and metastatic breast cancer has been observed in several studies. Whether discordant cases represent a true biological phenomenon and are due to clonal selection by chemotherapy, targeted anti-estrogen or anti-HER2 therapy or whether they may result from inconsistent measurement is still debated. This review article presents prospective and retrospective studies that have addressed these issues as well as the underlying responsible mechanisms. Finally, it concludes that a biopsy of metastatic disease can be recommended, when safe and easy to perform because treatment options might change for a significant proportion of patients.
Vorheriger Artikel The role of Positron Emission Tomography/Computer Tomography (PET/CT) in the diagnosis, staging, characterization, and therapy of breast cancer
Nächster Artikel Advanced breast cancer: new imaging techniques for detection of metastases
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Metadaten
Titel
Breast cancer: is there a need for biopsy of metastases?
verfasst von
Flora Zagouri, MD, PhD
Martin Filipits, PhD
Publikationsdatum
01.06.2012
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 2/2012
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-012-0005-4

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